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Target and research context definition
We start by understanding the target of interest, the disease area, the biological hypothesis and the development objective.
In neuroscience drug discovery, selecting the right therapeutic target is one of the most critical steps in reducing development risk. A target may appear promising in conventional models, but still fail to translate into meaningful biological effects in more complex human systems.
AxCellerate provides target validation services based on Brain-on-Chip technology and three-dimensional human-derived neuronal models. Our platform is designed to help research teams investigate whether a potential target is biologically relevant, functionally active and suitable for further development.
By enabling the study of neuronal activity, disease-related mechanisms and compound response in a more human-relevant environment, AxCellerate supports earlier and better-informed decisions in preclinical neuroscience programs.
Highlights
Target validation can support research teams that need to assess the relevance of a therapeutic target before advancing a candidate or research program.
Each project is structured around the client’s scientific question, the target biology and the experimental evidence required to support further decision-making.
Evaluation of potential therapeutic targets in neuronal models
Assessment of target relevance in disease-related contexts
Investigation of functional neuronal responses
Support for early drug discovery decisions
Validation of target engagement strategies
Comparison of biological effects across experimental conditions
Generation of translational evidence for CNS-related programs
Our process
AxCellerate follows a structured process to assess the biological relevance of therapeutic targets in human-relevant neuronal models. From the definition of the target and research context to experimental strategy, Brain-on-Chip validation, functional assessment and final reporting, each step is designed to support target prioritisation and better-informed preclinical decisions.
Discover how our Brain-on-Chip technology supports target validation in three-dimensional human-derived neuronal systems.
Each step is designed to help research teams investigate neurological mechanisms in a more human-relevant experimental environment.
We start by understanding the target of interest, the disease area, the biological hypothesis and the development objective.
We define the most suitable Brain-on-Chip model, testing conditions and readout strategy to assess target relevance in a human-relevant neuronal environment
The target is investigated using AxCellerate’s three-dimensional neuronal models, designed to reproduce relevant aspects of neuronal activity and biological response.
The platform enables the observation of functional and biological readouts that help determine whether the target produces meaningful effects in the selected model.
Results are analyzed and structured into a clear report to support internal R&D decisions, target prioritization or further preclinical development.
