AxCellerate supports compound screening with human-relevant Brain-on-Chip models for neuroscience drug discovery and preclinical research.
Compound screening is a critical step in neuroscience drug discovery. Research teams need to identify promising candidates, compare biological responses and detect potential safety concerns before advancing compounds into more complex and costly development phases.
Conventional screening systems can be useful for early evaluation, but they may provide limited insight into how compounds interact with human neuronal networks. This can make it difficult to prioritize candidates with confidence, especially in CNS-related programs where translational relevance is essential.
AxCellerate supports compound screening through Brain-on-Chip technology and three-dimensional human-derived neuronal models. The platform is designed to help research teams evaluate compound effects in a more human-relevant environment, generating functional and biological evidence to support early-stage decision-making.
AxCellerate’s Brain-on-Chip platform enables compound evaluation in advanced neuronal models designed to support preclinical screening workflows.
The technology can help by providing:
Three-dimensional human-derived neuronal systems allow compounds to be assessed in a biological environment that better reflects key aspects of human neuronal response.
Electrophysiological recording capabilities support the observation of neuronal activity and network response after compound exposure.
The platform is designed to support multiple experiments in parallel, helping research teams compare compounds, conditions or concentrations more efficiently.
Microfabricated compartments allow studies to be performed with small amounts of cells and compounds, supporting more efficient screening strategies.
Compound effects, potential neurotoxic signals and biological responses can be investigated earlier in the preclinical process.
The data generated can help research teams compare candidates and identify those that may deserve further investigation.
Advantages
AxCellerate provides a specialized approach for organizations that need to screen compounds in a more advanced and human-relevant neuronal model.
By integrating Brain-on-Chip technology into compound screening workflows, AxCellerate helps research teams generate more meaningful preclinical evidence and make better-informed decisions about which candidates to advance.
