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Scientific question definition
We start by understanding the disease area, the biological mechanism to be investigated and the research objective of the project.
Understanding neurological diseases requires experimental models that can reproduce key aspects of human neuronal biology. Conventional preclinical systems often have limited ability to reflect the complexity of human nervous system dynamics, reducing their translational value for neuroscience research.
AxCellerate provides disease modelling services based on Brain-on-Chip technology and three-dimensional human-derived neuronal models. Our platform is designed to support the study of neurological mechanisms, neuronal activity and disease-related biological responses in a controlled in vitro environment.
This service helps research teams investigate specific neurological conditions, explore disease pathways, evaluate biological responses and generate early evidence to support preclinical and translational research programs.
Highlights
Disease modelling can support research teams that need more relevant experimental systems to investigate neurological conditions and disease-related mechanisms.
Each project is designed around the client’s scientific objective, the biological question to be addressed and the level of model complexity required.
Modelling neurological and neurodegenerative disease mechanisms
Investigating disease-related neuronal activity
Studying functional responses in three-dimensional neuronal models
Supporting compound evaluation in disease-relevant contexts
Exploring patient-specific or mutation-specific research questions
Generating translational evidence for preclinical programs
Supporting research into CNS-related therapeutic strategies
Our process
AxCellerate follows a structured process to develop and apply disease-relevant neuronal models in a controlled preclinical setting. From the definition of the scientific question to model strategy, Brain-on-Chip development, functional assessment and final reporting, each step is designed to help research teams investigate neurological mechanisms and generate meaningful translational evidence.
Discover how our Brain-on-Chip technology supports disease modelling in three-dimensional human-derived neuronal systems.
Each step is designed to help research teams investigate neurological mechanisms in a more human-relevant experimental environment.
We start by understanding the disease area, the biological mechanism to be investigated and the research objective of the project.
We define the most suitable modelling approach, considering the type of neuronal model, disease-relevant features and required experimental readouts.
The selected model is developed or adapted using AxCellerate’s Brain-on-Chip platform, designed to support three-dimensional human-derived neuronal systems.
The model is used to observe relevant biological responses, neuronal activity and disease-related effects in a controlled preclinical setting.
Results are analyzed and structured into a clear report to support research decisions, compound evaluation or further translational development.
