Three-dimensional neuronal models
Human-derived neuronal systems provide a more relevant context to study complex neural mechanisms.
Brain-on-Chip platform
AxCellerate Technology
Brain-on-Chip innovation into preclinical neuroscience research.
Human-relevant neuroscience
A Brain-on-Chip platform for human-relevant neuroscience
AxCellerate technology was developed to address a critical limitation in preclinical neuroscience: the gap between conventional experimental models and the complexity of human neuronal biology.
Traditional 2D cell cultures and animal models can provide useful information, but they often struggle to reproduce the structure, activity and functional behaviour of human neural systems. This can reduce the predictive value of early-stage research and increase uncertainty in drug development, disease modelling and safety assessment.
AxCellerate’s Brain-on-Chip platform is designed to create a more human-relevant experimental environment. It enables the culture, imaging and electrophysiological recording of three-dimensional neuronal models, supporting the investigation of neuronal activity, compound response, disease mechanisms and target biology.
How it works
How the technology works
The AxCellerate platform integrates biological, technological and analytical capabilities into an advanced in vitro system.
Brain-on-Chip architecture
Microfabricated structures support controlled culture conditions and advanced experimental workflows.
Functional neuronal readouts
Electrophysiological recording capabilities allow researchers to observe neuronal activity and network response.
Glass-based microtechnology
The platform benefits from precision glass microfabrication, supporting transparency, biocompatibility and reduced compound absorption.
Efficient experimental design
The system is designed to work with small amounts of cells and compounds and to support parallel experimental workflows.
Benefits
Why AxCellerate technology matters for preclinical neuroscience research
More meaningful preclinical evidence by combining human relevance, functional analysis and experimental flexibility.
Human-relevant models
More human-relevant preclinical models help teams investigate neural mechanisms in a context closer to human biology.
Relevance
Structure
Context
Functional insights
Functional insights into neuronal activity support early investigation of compound response, target biology and network behaviour.
Activity
Response
Network
Decision support
The platform adds an advanced layer of evidence that can complement traditional workflows and strengthen translational research strategies.
Safety
Validation
Screening
Scientific foundation
From EUROSTARS NEUROCHIP to B2B research services
AxCellerate technology originated from the EUROSTARS NEUROCHIP project, a European research initiative focused on developing a novel Brain-on-Chip model for neurological drug development.
01
European research initiative
The project combined expertise in precision glass microfabrication, microelectrode systems, neuroscience and innovative in vitro assays.
02
Platform development
This scientific foundation led to the development of a platform designed to bring advanced Brain-on-Chip capabilities closer to real preclinical research needs.
03
Applied B2B services
Today, AxCellerate translates this technological foundation into B2B services for organizations working in neuroscience drug development, disease modelling, neurotoxicity assessment, compound screening, target validation and translational research.
Applications
Where the technology can be applied
AxCellerate’s Brain-on-Chip platform can support multiple research and industry needs across neuroscience and advanced safety assessment.
Early evidence for CNS decisions
Support early-stage decisions for CNS-related therapeutic programs and strengthen the connection between preclinical findings and human biological relevance.
Neurological drug development
Supporting early-stage decisions for CNS-related therapeutic programs.
Translational research
Strengthening the connection between preclinical findings and human biological relevance.
Disease-related mechanisms
Study disease-related mechanisms in advanced human-relevant neuronal systems, including mutation-specific or tailored biological research questions.
Neurodegenerative disease models
Studying disease-related mechanisms in advanced human-relevant neuronal systems.
Patient-specific modelling
Exploring mutation-specific, disease-specific or tailored biological research questions.
Response and risk signals
Investigate adverse effects on neuronal activity, compare candidate compounds and generate early functional evidence.
Neurotoxicity assessment
Investigating potential adverse effects on neuronal activity and network response.
Compound screening
Comparing candidate compounds and generating early functional evidence.
