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Research objective definition
We start by understanding the scientific question, the compound profile, the development context and the type of evidence required.
In neuroscience drug development, early decisions are often based on models that do not fully reproduce the complexity of human neuronal systems. This can limit the predictive value of preclinical data and increase uncertainty before entering more advanced development phases.
AxCellerate provides toxicity, safety and efficacy (if a suitable disease model is available) testing services based on advanced Brain-on-Chip technology and three-dimensional human-derived neuronal models. Our platform is designed to help research teams assess how new chemical entities interact with neuronal networks, identify potential safety concerns and investigate functional biological responses in a more relevant experimental environment.
The service supports early evaluation of compound effects, potential neurotoxic and safety responses and, when a suitable disease model is available, efficacy-related readouts. By combining neuronal models, microtechnology and electrophysiological recording capabilities, AxCellerate helps clients strengthen preclinical evidence and make more informed development decisions.
Highlights
Efficacy & Safety Testing can support research teams that need to evaluate the biological impact of compounds in human-relevant neuronal models.
Each project is defined according to the client’s scientific question, development stage and required experimental outputs.
Early assessment of compound response
Evaluation of potential neurotoxic effects
Safety-related preclinical studies
Functional readouts of neuronal activity
Efficacy assessment in available disease models
Comparison between candidate compounds
Support for translational research programs
Our process
AxCellerate follows a structured process to assess compound safety and potential neurotoxic effects in human-relevant neuronal models. From the definition of the research objective to model planning, Brain-on-Chip testing, functional data generation and final reporting, each step is designed to support clearer preclinical decisions.
Discover how our Brain-on-Chip technology enables functional analysis of neuronal response in a three-dimensional human-derived environment.
Each step is designed to help research teams investigate neurological mechanisms in a more human-relevant experimental environment.
We start by understanding the scientific question, the compound profile, the development context and the type of evidence required.
We define the most suitable experimental approach, selecting the appropriate neuronal model, testing conditions and readout strategy.
Compounds are tested using AxCellerate’s Brain-on-Chip platform, designed to support the analysis of neuronal response in a three-dimensional human-derived environment.
The platform enables relevant biological and functional readouts, including electrophysiological activity, helping assess compound effects on neuronal networks.
Results are analyzed and organized into a structured report to support preclinical decision-making, internal R&D evaluation or further development planning.
